This one was completely inevitable. AIDS is such an easy well to mine for trauma and drama, almost every single teen show from the point of the disease's discovery until now has based an episode around it. There's not much more I can comment on beyond that because AIDS, most agree, isn't funny. Except for when Captain Planet tackled it; THAT was hilarious.

The Kid Who Wouldn't Quit: The Brad Silverman Story -- September 23, 1987
A guy with Down's Syndrome goes to college. This one's based on a true story. It's not that unusual for a guy with Down's to go to college, though. Plenty of them do that. Give them a little credit, ABC....

The Day My Kid Went Punk -- October 23, 1987